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Martin Grumet
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| Address: |
604 Allison Road |
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Piscataway, NJ 08854 |
| Room: |
D423, Nelson Biology Laboratories |
| Phone: |
732-445-6577 |
| Email: |
mgrumet@rci.rutgers.edu |
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| One major focus of our laboratory is to study cell adhesion, a fundamental process that is critical for embryo development and maintenance of mature tissues. We study cell adhesion molecules (CAMs), which are anchored in the surface of cells and can link cells to adjacent cells and to the extracellular scaffold that surrounds cells by binding to specific receptors. We use a combination of molecular genetic, protein chemical, and cell biological techniques to identify domains in CAMs that mediate binding to neurons, glial cells, and extracellular ligands. Our second major focus is on radial glia cells, which have recently been shown to be neural stem cells. We are assessing the migration patterns of radial glial cells in uninjured and contused rat spinal cord. Molecular studies are in progress to search for factors responsible for the radial phenotype using microarray gene chip technology. |
Recent Papers:
1. Matzel, L.D., J. Babiarz, D.A. Townsend, H.C. Grossman and M. Grumet (2008) Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity. Genes Brain Behav 7: 470-80.
2. Saarikangas, J., J. Hakanen, P.K. Mattila, M. Grumet, M. Salminen and P. Lappalainen (2008) ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension. J Cell Sci 121: 1444-54.
3. Iseda, T., T. Okuda, N. Kane-Goldsmith, M. Mathew, S. Ahmed, Y.W. Chang, W. Young and M. Grumet (2008) Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion. J Neurotrauma 25: 334-49.
http://lifesci.rutgers.edu/~molbiosci/faculty/grumet.html
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