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Project Theme 11: Biointerfacial responses to electroactive polymeric substrates
Faculty Advisors:
Scheinbeim (CBE), Grumet (MBS), Shreiber (BME), Buettner (CBE)
Crossdisciplinary Bridging:
Materials Science, Cell Biology, Bioengineering, Polymer Chemistry
In this study, effects of neurotrophic and neurotropic factors on axonal guidance on patterned substrates will be investigated through in vitro and in vivo experiments. Many of these strategies rely on integration of neuronal explants into physiological environments, and although successful strategies for neuronal tissue culture have been developed, the incorporation of these cultures in functional architectures will rely on future progress in the control of biointerfaces.
In particular, extracellular ligand binding regions of cell adhesion molecules including L1 will be assembled on anisotropically stretched films or foams of piezoelectrically actuatable polymer substrates that thereby serve as guides to direct axonal growth. The use of electroactive polymer interfaces presents a novel opportunity to actively control biointerfacial processes during tissue growth. Previous studies by Scheinbeim et al, using poly(l-lactide) piezoelectric films as a substrate, show an enhancement of neurite growth on the polymer surface (at right) (43), however, these studies did not take into account the vibration frequency of the polymer material nor the sign (or changing signs) of the surface charge being generated. A careful study of these interactions is needed to determine and understand the effects of the electroactive polymer film surface along with its use as a way of enhancing cell growth and, in addition, of directing it. These studies may lead to new methods of controlling neurite outgrowth and an improved understanding of the effects of surface charges in piezoelectric and ferroelectric polymers. Patterned 2-D substrates and 3-D simulations of adjacent regions containing inhibitors and promoters of neurite outgrowth will provide unique models for neurogenerative interfaces.
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| Major Events |
IRIF:Megan Anderson Fri., 12/11 in BME-122, 12-1 pm
Enhanced Survival of Progeny of Neural Stem Cells in Response to Trace Eyeblink Conditioning
IRIF:Andrew LHuillier Thurs., 11/19 in BME-122, 12-1pm
Mesenchymal Stem Cell Mediated Immunosuppression and IDO Metabolites
RESCHEDULED: Bioindustry Ethics Luncheon Part II w/ David Finegold (IGERT Fellows ONLY) 11/5/09
Part II of the Ethics Luncheon will be rescheduled to the Spring semester IRIF schedule.
IRIF:Dr. Debu Banerjee 10/22 in BME-122, 12-1 pm
Therapeutic applications of bone marrrow derived Mesenchmal stem cells
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| More News |
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Congratulations!
IGERT Fellows Aaron Carlson and Mohamed Sadik took 1st and 3rd place (respectively) in the Poster Presentations at the 3rd Annual NJ Stem Cell Symposium held Thursday, September 24, 2009. Aaron Carlson's poster was titled “3-D Electrospun Polymer Scaffolds Promote Human Embryonic Stem Cell Self-Renewal and Controlled Organization". Mohamed presented “Electroporation-Mediated Molecular Delivery”. Jonathan Davilla took 2nd place with “Identification of Biologically Functional microRNAs in Human ESCs by Ago2 Immunoprecipitation and Sequencing”. The keynote address was delivered by Hakim Djaballah, PhD of the Memorial Sloan Kettering Cancer Center.
Congratulations to Professor Ki-Bum Lee, Stem Cell IGERT Faculty in Chemistry and Chemical Biology, who is the recipient of the NIH Director’s New Innovator award, 2009.
The NIH Director's New Innovator Award program is designed specifically to support unusually creative early stage investigators with highly innovative research ideas at an early stage of their career.
IGERT fellow wins award:
Congratulations to IGERT fellow Nicole Plourde who was recipient of the 2009 Schering-Plough Innovation Award. She was presented with an awards plaque and a check for $5000 at a ceremony on Thursday, April 16th.
Chris Ricupero featured on Epigenie interview
Follow link here for full interview.
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