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Project Theme 5: Ceramic Nanoscale Interfaces for Biomolecular Templating
Faculty Advisors:
Riman (CME), Garofalini (CME), Safari (CME), Denhardt (MBS)
Crossdisciplinary Bridging:
Materials Science and Engineering, Cell Biology, Physical Chemistry
Inorganic materials such as hydroxyapatite offer the ability to self assemble (template) biologically relevant molecules along with the advantage of possessing tunable resorption/biomineralization. The efforts at Rutgers utilize hydrothermal crystallization technologies to make a large family of hydroxyapatites (HA) with control over cation and anionic subsitution. Furthermore, via control of the relative growth rates of various crystallographic planes, the morphology can be controlled down to nanometer scale to build substrate materials with dominant planes that are optimum for templating the biomolecules (26). A process invented at Rutgers, referred to as fluid-forming, enables conformal dense coverage of surfaces with crystals in such a manner. Thus, even a material with a curved surface can have uniform crystallographic orientation at the interface and thus enable the self-assembly of biologically relevant molecules at that
Molecular dynamic simulations of water distribution at bioceramic interfaces.
interface. This thrust will incorporate "osteopontin", a key ligand for cell adhesion and motility co-discovered by Denhardt at Rutgers(27), as a biological cue on the templated bone-mimetic substrates. The actual nanotemplating of the biomolecule can benefit from successful efforts of the project by Ling and coworkers described above in Theme 4. Additionally, molecular dynamics simulations will be performed to track the elucidate the nanoscale distribution within the hydroxyapatite-based surfaces, prior to templating of the biomolecules.
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| Major Events |
IRIF:Megan Anderson Fri., 12/11 in BME-122, 12-1 pm
Enhanced Survival of Progeny of Neural Stem Cells in Response to Trace Eyeblink Conditioning
IRIF:Andrew LHuillier Thurs., 11/19 in BME-122, 12-1pm
Mesenchymal Stem Cell Mediated Immunosuppression and IDO Metabolites
RESCHEDULED: Bioindustry Ethics Luncheon Part II w/ David Finegold (IGERT Fellows ONLY) 11/5/09
Part II of the Ethics Luncheon will be rescheduled to the Spring semester IRIF schedule.
IRIF:Dr. Debu Banerjee 10/22 in BME-122, 12-1 pm
Therapeutic applications of bone marrrow derived Mesenchmal stem cells
View all major events >>
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| More News |
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Congratulations!
IGERT Fellows Aaron Carlson and Mohamed Sadik took 1st and 3rd place (respectively) in the Poster Presentations at the 3rd Annual NJ Stem Cell Symposium held Thursday, September 24, 2009. Aaron Carlson's poster was titled “3-D Electrospun Polymer Scaffolds Promote Human Embryonic Stem Cell Self-Renewal and Controlled Organization". Mohamed presented “Electroporation-Mediated Molecular Delivery”. Jonathan Davilla took 2nd place with “Identification of Biologically Functional microRNAs in Human ESCs by Ago2 Immunoprecipitation and Sequencing”. The keynote address was delivered by Hakim Djaballah, PhD of the Memorial Sloan Kettering Cancer Center.
Congratulations to Professor Ki-Bum Lee, Stem Cell IGERT Faculty in Chemistry and Chemical Biology, who is the recipient of the NIH Director’s New Innovator award, 2009.
The NIH Director's New Innovator Award program is designed specifically to support unusually creative early stage investigators with highly innovative research ideas at an early stage of their career.
IGERT fellow wins award:
Congratulations to IGERT fellow Nicole Plourde who was recipient of the 2009 Schering-Plough Innovation Award. She was presented with an awards plaque and a check for $5000 at a ceremony on Thursday, April 16th.
Chris Ricupero featured on Epigenie interview
Follow link here for full interview.
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